What is the difference between despite and in spite of? Here’s how to use them in a sentence.
DESPITE AND IN SPITE OF DIFFERENCE – Here are some of the things to take note when it comes to using them in a sentence.
In the English language, we usually encounter words that seem to be similar in usage, but are really used differently. Some of these words are “despite” and “in spite of.” Most of us are confused about using these two words in a sentence. Often, they are used interchangeably, but understanding their differences and knowing certain considerations can help you improve your grammar, writing, and correct usage in a sentence.

These two words are prepositions, and prepositions are words that show the relationship of a noun or a pronoun and another word in a sentence. It often tells where or when something happens, or shows direction, cause, or manner. Typically, they are used before nouns, gerunds, and phrases containing a relative pronoun.
DESPITE
This is always written as one word and never “despite of.” This is more formal and shorter.
IN SPITE OF
This is always written in three words. “Inspite of” is wrong. This is more informal and longer.
Both mean “without being affected by the particular factor mentioned,” synonymous with “even though,” “notwithstanding,” and “regardless of.”
How to use them in a sentence?
- They should be placed at the beginning of the dependent clause.
Examples:
- Despite the rain, the program went on as planned.
- Despite feeling tired, he finished all of his homework.
- In spite of her sickness, she went to work
- In spite of their differences, their relationship worked out.
Remember these things when constructing a sentence using these words:
- Of the two, “despite” is less wordy and the more concise option.
- Do not put “of” after despite. As mentioned, “despite of” is wrong.
- The idioms in spite of oneself and despite oneself mean doing something unintentionally or unwillingly, even though one did not plan or want to do it.